Development of new HPLC method for identification of metabolic degradation of N-pyrrolylhydrazide hydrazones with determined MAO- B activity in cellular cultures

Alexandrina Mateeva; Lily Peikova; Magdalena Kondeva-Burdina; Maya Georgieva

doi:10.3897/pharmacia.69.e78417

Research Article

Pharmacia 69(1): 15-20
https://doi.org/10.3897/pharmacia.69.e78417 (05 Jan 2022)

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A. Deruish, G. V. Karakashev, A. I. Ukolov, I. G. Zenkevich (2023)
Hydrolytic Stability of Unsubstituted Hydrazones of Aromatic Carbonyl Compounds in Reversed-Phase HPLC. Journal of Analytical Chemistry 78: 222.

DOI: 10.1134/S106193482302003X

Emilio Mateev, Maya Georgieva (2023)
Biological evaluation, molecular docking and DFT calculations of pyrrole-based derivatives as dual acting AChE/MAO-B inhibitors. Pharmacia 70: 1019.

DOI: 10.3897/pharmacia.70.e113014

Alexandrina Mateeva, Magdalena Kondeva-Burdina, Lily Peikova, Maya Georgieva (2023)
Optimization and validation of RP-HPLC method for evaluation of pyrrole -containing hydrazones in isolated rat synaptosomes. Pharmacia 70: 1015.

DOI: 10.3897/pharmacia.70.e113039

Emilio Mateev, Magdalena Kondeva-Burdina, Maya Georgieva, Alexandrina Mateeva, Iva Valkova, Virginia Tzankova, Alexander Zlatkov (2024)
Synthesis, Biological Evaluation, Molecular Docking and ADME Studies of Novel Pyrrole-Based Schiff Bases as Dual Acting MAO/AChE Inhibitors. Scientia Pharmaceutica 92: 18.

DOI: 10.3390/scipharm92020018

Alexandrina Mateeva, Magdalena Kondeva-Burdina, Paraskev Nedialkov, Lily Peikova, Maya Georgieva (2023)
Development of Hyphenated Techniques and Network Identification Approaches for Biotransformational Evaluation of Promising Antitubercular N-pyrrolyl hydrazide-hydrazone in Isolated Rat Hepatocytes. Chromatographia 86: 497.

DOI: 10.1007/s10337-023-04260-5

A. Deruish, G. V. Karakashev, A. I. Ukolov, I. G. Zenkevich (2023)
Hydrolytic Stability of Unsubstituted Hydrazones of Aromatic Carbonyl Compounds in Reversed-Phase HPLC. Журнал аналитической химии 78: 166.

DOI: 10.31857/S0044450223020032

Hasan Erdinç Sellitepe, Göknil Coşkun, Kaan Birgül, Mert Ülgen, İnci Selin Doğan (2024)
Metabolic stability of a hydrazone derivative: N′-[(4-chlorophenyl)methylidene)]-4-[(4-methylphenyl)sulfonyloxy]benzohydrazide. Turkish Journal of Analytical Chemistry 6: 97.

DOI: 10.51435/turkjac.1514896

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