Research Article
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Article title
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Abstract
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Keywords
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Introduction
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Materials and methods
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Chemicals, cell lines, and culture conditions
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Commercial kits
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Preparation of TQ, silymarin and cisplatin working solutions
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Antiproliferative assay
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Calculation of inhibitory concentration (IC₅₀)
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Calculation of combination index (CI)
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Calculation of resistance fold
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Colorimetric assay of caspase-3 activity in EMT-6/P and EMT-6/CPR cells ()
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Mice
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Establishing regimens for the in vivo experiment
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Tumor inoculation and antitumor activity in vivo
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Evaluation of liver function in treated mice
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Evaluation of kidney function in treated mice
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Data analysis
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In vitro results
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Anti-proliferative activity of TQ and silymarin as single treatments on both EMT-6/P and EMT-6/CPR cell lines
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Anti-proliferative effect of cisplatin treatment on EMT-6/P, EMT-6/CPR cell lines
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Anti-proliferative effect of TQ and silymarin combination treatment on EMT-6/P, EMT-6/CPR cell lines
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Combination index (CI) calculations
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Resistance fold
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Effect of TQ, silymarin, cisplatin and their combination on caspase-3 levels in EMT-6/P and EMT-6/CPR cells
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In vivo Results
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Antitumor effects of TQ, silymarin, their combination and, cisplatin on EMT-6/P cells implanted in mice
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Antitumor effects of TQ, silymarin, their combination and, cisplatin on EMT-6/CPR cells implanted in mice
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Liver toxicity evaluation in mice
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Kidney toxicity evaluation in mice
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Discussion
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Conclusion
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Recommendations
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Author contributions
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Ethical approval
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Acknowledgments
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References
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