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Article title
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Abstract
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Keywords
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Introduction
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Experimental part
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Materials and method
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Chemistry
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General procedure for the synthesis of N-(quinolin-6-yl)propanehydrazonoyl chloride (8)
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General procedure for the synthesis of Amidrazone (10a–l)
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1-(Piperazin-1-yl)-1-(2-(quinolin-6-yl)hydrazineylidene)propan-2-one (10a)
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1-Morpholino-1-(2-(quinolin-6-yl)hydrazineylidene)propan-2-one (10b)
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1-(2-(Quinolin-6-yl)hydrazineylidene)-1-thiomorpholinopropan-2-one (10c)
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Ethyl-4-(2-oxo-1-(2-(quinolin-6-yl)hydrazineylidene)propyl)piperazine-1- carboxylate (10d)
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1-(4’-(3’’-Hydroxyphenyl)piperazin-1-yl)-1-(2-(quinolin-6- yl)hydrazineylidene)propan-2-one (10e)
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1-(4’-(4’’-Nitrosophenyl)piperazin-1-yl)-1-(2-(quinolin-6- yl)hydrazineylidene)propan-2-one (10f)
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1-(4’-(2’’-Hydroxyphenyl)piperazin-1-yl)-1-(2-(quinolin-6-yl) hydrazineylidene) propan-2-one (10g)
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1-(4’-(4’’-Chlorophenyl)piperazin-1-yl)-1-(2-(quinolin-6- yl)hydrazineylidene)propan-2-one (10h)
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1-(4’-Phenylpiperazin-1-yl)-1-(2-(quinolin-6- yl)hydrazineylidene)propan-2-one (10i)
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1-(4’-(4’’-Hydroxyphenyl)piperazin-1-yl)-1-(2-(quinolin-6- yl)hydrazono)propan-2-one (10j)
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1-(4’-Phenylpiperazin-1-yl)-1-(2-(quinolin-6- yl)hydrazineylidene)propan-2-one (10k)
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1-(4’-(pyridin-2-yl)piperazin-1-yl)-1-(2-(quinolin-6-yl)hydrazineylidene)propan-2-one (10l)
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Molecular modeling
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Computational docking
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Ligand preparation for LibDock
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Toxicity prediction using EC50 Daphnia calculations
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Data set
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In vitro anticancer screening
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Collection of X-ray diffraction data and structure analysis of compound (10b)
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Results and discussion
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Chemistry
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X-ray structure determination of (10b)
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Computational docking
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Conclusions
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Acknowledgments
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References
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Supplementary materials
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