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  • Article title
  • Abstract
  • Keywords
  • Introduction
  • Materials and methods
    • Development and formulation optimization
    • Nanoemulsion preparation and assessment
    • In-vitro drug diffusion study
    • Nanoemulgel preparation and assessment
      • Rheology behaviors
      • Spreadability
      • pH analysis
      • Drug content uniformity
    • Ex-vivo skin deposition and permeation investigation
    • Stability assessment
    • Statistical analysis
  • Results and discussion
    • Formulation assessment
    • Nanoemulsion preparation components
    • Effect of Km on nanoemulsification
    • Evaluation of PHCl nanoemulsions
    • Investigation of in-vitro drug diffusion
    • Morphology rationalization with AFM
    • Nanoemulgel assessment and evaluation
    • Skin deposition and permeation outcomes
    • Physical stability study findings
  • Conclusions
  • Acknowledgments
  • References
  • Appendix 1
  • Supplementary material
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