Research Article
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Article title
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Abstract
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Keywords
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Introduction
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Materials and methods
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Materials
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Methods
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Preparation of NAC-loaded SLNs
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Characterization of optimized formulation
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Effect on EE
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Effect of % DR
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Effect of PS and ZP
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Scanning Electron Microscopy (SEM) study
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In vitro drug release study
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FT-IR study
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DSC study
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XRD study
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Animal studies
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Experimental design
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Biochemical parameters
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Estimation of lipid peroxidation (LPO)
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Antioxidant assays Enzymatic antioxidant- Glutathione peroxidase (GPx)
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Non-enzymatic antioxidant Reduced glutathione (GSH)
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Liver toxicity markers
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Assay of serum glutamate oxaloacetate transaminase (SGOT)
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Assay of Serum Glutamate Pyruvate Transaminase (SGPT)
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Estimation of Alkaline Phosphatase (ALP)
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Estimation of Lactate dehydrogenase (LDH)
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Histopathological examination
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Statistics
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Results
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Preparation of NAC -loaded SLN formulations
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Statistical analysis and optimization of NAC-SLNs by BBD
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Effects on EE
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Effects on >DR
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Effects on ZP
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Effects on PS
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Optimization and validation of the model
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Effect on EE
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Effect on % DR
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Effect on PS and ZP
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In vitro drug release
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SEM
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FT-IR study
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DSC study
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XRD study
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Effect of NAC-SLNs on LPO
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Effect of NAC-SLNs on antioxidant levels
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Effect of NAC-SLNs on liver enzymes and LDH
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Effect of NAC loaded SLNs on hepatic architecture
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Discussion
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Conclusion
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Ethical approval
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Acknowledgements
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References
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