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  • Disease – COVID-19
    • Flow
    • Laboratory characteristics of COVID-19 complications
  • Etiological agent – SARS-CoV-2
  • Cause of mortality
  • Cytokine storm
  • The aberrant activated NLRP3 inflammasome cause the cytokine storm
  • Can SARS-CoV-2 activate NLRP3 inflammasome?
  • Which cells are responsible for the development of the cytokine storm?
  • Why does SARS-CoV-2 spread so easily?
  • Is there a connection between viral load, replication and the hyperactivation of NLRP3 inflammasome?
  • You are patient with confirmed Covid-19 - what doing?
    • World Health Organization recommendations for Covid-19 treatment
      • Outpatients treatment
      • Molnupinavir (Lagevrio)
      • Remdesivir
      • Inpatient treatment
      • Tocilizumab and sarilumab
      • Baricitinib
      • Remdesivir is with weak or conditional recommendation in favour
      • Price list of WHO-recommended Medicines
    • Treatment of Covid-19 with inhaled bromhexine, higher doses of colchicine and hymecromone
      • Why Bromhexine hydrochloride?
      • What are the results so far for treating COVID-19 with BHH?
      • What accounts for the discrepancy between expected and actual results in the use of BHH for the treatment of COVID-19?
      • When and how to apply BHH to achieve maximum effect in the treatment of COVID-19
      • Colchicine
      • Colchicine properties and mechanisms of action
      • Colchicine accumulates in leukocytes!
      • Why attempts to prove a curative effect of colchicine against COVID-19 have failed?
      • Our therapeutic regimen
      • Mortality in 452 inpatients treated with higher colchicine doses was about 5 times lower than the control group
      • Are the higher doses of colchicine dangerous?
      • Colchicine toxicity in drug-drug interactions
      • Hymecromone inhibits the hyaluronan synthesis and storm
  • Acknowledgements
  • References
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