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  • ContentsContents
  • Article InfoArticle Info
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  • Article title
  • Abstract
  • Keywords
  • Introduction
  • Materials and methods
    • Materials
    • Preparation of empty ChNP and PNNP
    • Physical characterization of ChNP and PNNP
    • Entrapment efficiency (EE) of PNNP
    • Morphology investigation
    • Fourier transform infrared (FTIR) spectroscopy
    • Thermal analysis
    • Cell viability test using CCK-8 assay
    • Quantification DNA damage by alkaline comet assay
    • Assessment of DNA single strand breaks (SSBs) by FHA
    • Investigation of cellular morphological change by Hoechst 33342 nuclear staining
    • BTB proteins expression using immunofluorescence assay
  • Results and discussion
    • Physicochemical characterization of nanoparticles
    • Morphology investigation
    • Fourier transform infrared spectroscopy (FTIR)
    • Thermal analysis
    • Cell viability assay on ChNP and PNNP with CCK-8
    • Quantitative analysis of DNA damage by alkaline comet assay
    • Evaluation of DNA breakage by FHA
    • Imaging of cellular morphological change by Hoechst 33342 nuclear staining
    • Analysis of BTB proteins expression
  • Conclusion
  • Funding
  • Conflict of Interest
  • Acknowledgments
  • References
  • Supplementary material
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