The literature search on the MEDLINE and EBSCO databases was conducted in May–June 2021. The keywords used included “patient satisfaction”, “pharmacy service”, “hospital pharmacy service”, and “clinical pharmacy service”. The literature search report of flow diagram followed to the the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).

The inclusion criteria for articles are original articles, full papers, article in English, and published in 2011–2021. Articles excluded have criteria that do not discuss clinical pharmacy service and do not contain the desired keywords.

The extracted data are references containing the main author’s name and year of publication, country, participants, the number of participants, place of service, type of clinical pharmacy service, study design, satisfaction measurement instrument, factors influencing patient satisfaction, results, and funding sources.

Table 2 presents 9 articles on patient satisfaction with counseling services. Generally, the patients showed high satisfaction with clinical pharmacy services. Patient satisfaction with counseling in Saudi Arabia was reported to have different levels. According to the study conducted by Al-Arifi. (2012) , most patients were very satisfied with the performance and professionalism of pharmacists with satisfaction indicators such as the role in counseling, patient compliance, and providing appropriate drug information. The higher the frequency of counseling the greater the satisfaction rating. However, there are several barriers counseling moments as include lack of privacy and an inadequate number of qualified pharmacists (Al-Arifi 2012).

Another study from Saudi Arabia reported that the level of is low patient satisfaction with score was 2.97 ± 0.65 out of 5 scale (Alotaibi et al. 2021). The influencing factors were pharmacy facilities, pharmacy services, and counseling. Most of the patient‘s reported that they were not satisfied with history taking practice by the pharmacists (Score: 3.17 ± 1.60), provision of instructions for side effects or interactions (Score: 3.08 ± 1.64), and dissemination of information on storage conditions (score: 3.11 ± 1.63). Other causes are to limited number of pharmacists and pharmacy staff in the hospitals, increased workload, lack of continuous education for pharmacy service providers as well as lower standards of pharmacy services and less attention of regional health departments on pharmacy standards and practice (Alotaibi et al. 2021).

In addition, the study conducted by Alkhoshaiban A et al. (2019) on 102 patients with type II diabetes showed that the intervention program has improved medication adherence, satisfaction, and HbA1c level among patients with type II diabetes. Medication adherence, satisfaction, and HbA1c level were all associated with gender. The improvement in medication adherence, satisfaction, and HbA1c level demonstrates the pharmacist’s critical role in the patient’s overall health management (Alkhoshaiban et al. 2019).

The study conducted by Hale A et al. (2016) in Australia on 200 patients scheduled for surgery reported that most of the patients had a high satisfaction with pharmacist prescriber consultations. This is because more than 97% patients were satisfied with counseling services in consultations with pharmacists. These are all key components in forming an effective partnership with a patient and adherence with treatment plans. (Hale et al. 2016).

In Romania, Iancu et al. (2014) study also showed a high level of patient satisfaction. The majority of respondents (47.65%) estimated that they spent 5–10 minutes with the pharmacist. 95.85% of patients said the pharmacist provided them with all of the information they required, and 76.51 percent of participants said they were very satisfied with the pharmacist interview (5 on a 1–5 scale). The pharmacist provided the majority of the respondents with all of the information they need, and the interview with the pharmacist left them extremely satisfied. The counseling activities are carried out by pharmacists in a very professional manner, in accordance with patient feedback during counseling. Patients received advice on drug administration information such as the route of administration, how to take the drug with food, the dose used, and the length of treatment. (Iancu et al. 2014).

Study conducted in Canada in 2021 on 35 patients experiencing anticancer therapy showed very high patient satisfaction with counseling services, where the average satisfaction score was 5.90–6.70 out of 7 possibilities (Munro et al. 2021). Patient satisfaction is based on indicators of comfort during counseling, ease of delivery of treatment information, and good communication between patients and pharmacists (Munro et al. 2021). The pharmacist provided the majority of respondents with all of the information they required, and the interview left them extremely satisfied with their relationships with oncology pharmacists: the feeling of being supported by the pharmacist may not only improve emotional well-being but also improve the quality of care received if patients communicate with pharmacists about emerging issues and adhere to recommended pharmaceutical treatments (Munro et al. 2021). In addition, previous study conducted on 62 female patients in a rheumatology clinic showed high patient satisfaction with indicators of providing information, service techniques, ethical competence, and good communication by pharmacists to patients (Hall et al. 2017).

In Iran, study conducted on 326 patients showed high patient satisfaction (Fesharaki 2019). This satisfaction is influenced by the component of verbal communication by pharmacists while providing counseling, with indicators of the tone of voice and body language, waiting time for counseling, and the atmosphere of the pharmacy (Fesharaki 2019). Furthermore, non-verbal communication such as maintaining eye contact, showing interest in providing information about drugs, and maintaining expression when interacting with patients should also be mastered. Counseling with verbal and non-verbal communication positively increases patient satisfaction since they feel happier while conversing with the pharmacists (Fesharaki 2019).

Table 3 displays eight articles on patient satisfaction with drug therapy monitoring services in clinical pharmacy. Generally, 7 articles showed high satisfaction, but one articles showed low patient satisfaction with clinical pharmacy services.

Patient satisfaction with drug therapy monitoring services in the United States is reported to have different levels. According to Martin and Faber (2016), 64 patients with Hepatitis C Virus (HCV) treatment had high satisfaction with drug therapy monitoring services by pharmacists. The clinical pharmacist-run HCV treatment program provides services to improve medication access, education about medications and adherence, and ADR management. Patients rate their overall satisfaction with the services provided in the “great” category (Martin and Faber 2016). This contrasts with the findings of Reich et al. (2018) study, that found that poor communication between prescribers and patients was the cause of low patient satisfaction (Reich et al. 2018).

According to Beyene et al. (2021) study in New Zealand, patients under warfarin drug therapy monitoring registered with the Community pharmacist-led Anticoagulant Management Service (CPAMS) were very satisfied with the drug delivery management services provided with the mean overall satisfaction score was 94.5% ± 13.1 (range 3%–100%). Furthermore, patient satisfaction was identified from factor analysis of patient-centered communication, pharmacist competence, patient-pharmacist relationship, confidence in CPAMS, and pharmacist environment. This study also stated that the increasing age and the more frequent visits to the pharmacy are positively related to patient satisfaction (Beyene et al. 2021).

Study of satisfaction with drug therapy monitoring services in South Africa on 300 patients with antiretroviral drug therapy monitoring for four months or more showed a high satisfaction level but patients expressed some dissatisfaction with certain dimensions of the quality of care, including an inability to talk to health workers about their treatment and problems, time spent in queues waiting to be examined and facility cleanliness (Bezuidenhout et al. 2014). In Canada, 107 out of 112 patients receiving chemotherapy were very satisfied with the monitoring regimen of chemotherapy drug therapy. This is influenced by satisfaction and follow-up care in chemotherapy patients. Satisfaction levels were very high in questions that evaluated the information provided by the pharmacist. A pharmacist led proactive follow-up program is an effective method for clinical pharmacy services (Crespo and Tyszka 2017).

Based on another study, patients in Taiwan with a history of more than one disease and monitored for therapy with more than one prescription had high satisfaction, as evidenced by a high level of confidence in pharmacists. Patient trust is positively related to patient satisfaction and cooperation between patients and clinical pharmacists. Thus, pharmacists should spend more time on each patient for can provide detailed information (Chou et al. 2019). In addition, a study in Lebanon on musculoskeletal patients who received more than one prescription stated the patients were satisfied with drug therapy services. This is influenced by satisfaction with pharmacist care for patients with musculoskeletal conditions, those using prescription opioids (Sites et al. 2018).

Table 4 shows 3 articles on patient satisfaction with the support programs. Generally, the patients receiving the support program felt comfortable and reported high satisfaction.

According to Hatton et al. (2018) study in the United State, patients were satisfied with both Clinical Video Teleconferencing (CVT) and face-to-face consultations. The consultation through CVT did not differ from face-to face consultations. Factors that affect satisfaction were patient convenience level, patient satisfaction with pharmacist communication, competence, and clinical skills by pharmacist (Hatton et al. 2018).

In addition, a study in the United States was conducted by Mooney EV et al. (2018) on patients receiving aripiprazole, paliperidone, palmitate, and risperidone treatment. These patients were reported to have high satisfaction with the LAIA program with factors such as privacy, ease of making consultation appointments, convenience to pharmacy services, location convenience, and level of confidence in pharmacists (Mooney et al. 2018)

Another study concerning the patient support program conducted in Switzerland by Bourdin, A. et al. (2020) on 17 patients who participated in The Fingolimod Patient Support Program (F-PSP) program showed high satisfaction assessed based on safety and compliance with treatment using the F-PSP method. The pharmacist-led consultations with medication-related and holistic support were well received by the patients. Patients’ involvement in their health is boosted by consultations based on motivational technique and the use of provided tools. Furthermore, pharmacists tend to contribute significantly to patient management from the perspective of patients (Bourdin et al. 2020).

Table 5 shows seven articles that discuss patient satisfaction with pharmaceutical care services. While 6 of 7 articles show high patient satisfaction, 1 article shows low patient satisfaction.

In the United Arab Emirates (UAE), a study conducted by El-Sharif et al. (2017) reported that 77.1% of patients were satisfied with pharmaceutical care services. This is influenced by several factors, such as experience, trust, courtesy, and confidence of pharmacists when providing pharmaceutical services. However, there are still many patients who are not aware of what information is expected and should be received regarding the drugs they receive from pharmacists. Therefore, pharmacists need to fully practice their role for the benefit of their patients (El-Sharif et al. 2017). Another study in the UAE was also conducted by Saad Ali et al., (2019) reported that 72.8% of patients were very satisfied with simple, understandable language used by the pharmacists. However, the patients were not satisfied with the privacy while pharmacists discussed with patients (Saad Ali et al. 2019).

In a study conducted by Abebe et al. (2016) in Ethiopia on 291 HIV/AIDS patients using a type 5 Likert scale instrument through interviews, patient satisfaction was reported to be relatively low with an average satisfaction level of 2.46 out of a 5-point Likert scale. Meanwhile, overall patient expectations for pharmaceutical services are very high. This is influenced by uncomfortable waiting rooms, private counseling rooms, and waiting times (Abebe et al. 2016).

The study conducted by Soeiro, O.M., et al. (2017) on 8,803 patients in five geopolitical regions of Brazil stated that 58.4% were satisfied with the services received. This is influenced by the patients’ comfort feeling when communicating with pharmacists (Soeiro et al. 2017).

Another study was also conducted by Mináriková et al. 2016 in Slovakia, using a type 5 Likert scale instrument. A total of 2,844 patients reported that overall patients were very satisfied with pharmaceutical care services: interpersonal relationships (1.85±0.598; 86.7% highly satisfied respondents) and general satisfaction (2.02±0.643; 71.3% highly satisfied respondents). Managing therapy received a lower score (2.24±0.704; 65.4% highly satisfied respondents). Prescription (70.4%) and over-the-counter drugs were the most common reasons for visiting a community pharmacy (70.4%) (Mináriková et al. 2016). Therefore, pharmacists need to improve their professional behavior in providing pharmaceutical care to patients.

This literature review has several limitations. First, because of insufficient information about the health care system in countries where studies were conducted, this review does not discuss the difference in the health care system that could lead to different satisfaction levels. Second, the level of satisfaction could not be generalized, because the different cultures could influence the level of satisfaction of patients. However, this article could give an overview of patient satisfaction with clinical pharmacy services and the affecting factors.