Review Article |
Corresponding author: Susilo Rini ( susilorini@uhb.ac.id ) Academic editor: Luisa Pistelli
© 2023 Susilo Rini, Soetrisno Soetrisno, Tri Rejeki Andayani, Suminah Suminah.
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Citation:
Rini S, Soetrisno S, Andayani TR, Suminah S (2023) Complementary and alternatives care for postpartum preeclampsia: A scoping review. Pharmacia 70(4): 867-875. https://doi.org/10.3897/pharmacia.70.e110572
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This scoping review aimed to examine the existing evidence on complementary and alternative medicine interventions for preeclampsia, emphasizing empowering midwives in postpartum treatment. Three databases (PubMed, Web of Science, Scopus) were used following the PRISMA-2020 guidelines to find articles from January 2012 to December 2022 and synthesized using Rayyan AI software. A total of 707 articles were initially identified, 7 were included in the review. Traditional Chinese Medicine combined with Western medicine showed promise in treating severe preeclampsia. Massage therapy reduced anxiety, aromatherapy positively affected postpartum well-being, and warm foot therapy reduced swelling associated with postpartum preeclampsia. Using herbal ingredients, lavender aromatherapy, magnesium sulfate, massage, and physical therapy contributed to successful postpartum preeclampsia management. Complementary and alternative medicine, collaboration with community health workers, clear guidelines, targeted training, and future research are crucial for effective postpartum preeclampsia management.
complementary, alternative care, postpartum, preeclampsia
Preeclampsia, often known as PE, is one of the most common causes of sickness, disability, and mortality among pregnant women and their newborns (
During the past decade, doctors have been increasingly pushed to utilize medications “off-label” in an effort to determine whether or not they are effective against PE (
Implementation of complementary and alternative medicine for preeclampsia requires professional health care providers. When it comes to the management of pregnancy and the process of giving birth, midwives are the primary caregivers (
This review comprehensively examines the pathophysiology of PE with a specific focus on the mechanisms underlying the clinical features, the role of midwife and community health workers responsibility on postpartum women, pharmacological therapy for PE, complementary and alternative care for PE, the postpartum physiology changes, and the current implementation of complementary and alternative care for postpartum PE.
A systematic literature search was conducted, and articles published between January 2012, to December 2022 were included in this scoping review. This scoping review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines used to guide this review (
Three databases (PubMed, Scopus, and Web of Science (WoS)) were searched for articles containing the keywords “preeclampsia” AND “complementary treatment,” and the results were compiled. Articles written in languages other than English and abstracts that were never expanded upon were not considered.
Studies documenting the application of complementary and alternative care for postpartum PE were included. The inclusion criteria such as case study, randomized clinical trial, preeclampsia, post natal preeclampsia, and conference proceeding. On the other hand, review study, animal study, commentary, editorials, books, newspaper, non-open access, non English article were excluded.
Four independent reviewers (SR, ST, TRA, and SM) screened the titles and abstracts of all identified articles for eligibility using the predefined inclusion and exclusion criteria using Rayyan AI software (
Complementary and Alternative Medication (CAM) Care for Preeclampsia Treatment.
No | Author | Year | Country | Title | Intervention | Duration of intervention | Participants | Outcome |
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1 |
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2019 | Egypt | Effect of stretching exercises versus autogenic training on preeclampsia | They were split up into two groups with an equal number of members in each; | 6 weeks | 40 preeclamptic primiparous women | Significant decrease in systolic blood pressure, diastolic blood pressure and proteinuria in both group A and B after 6 weeks of treatment |
Group A: 20 women(stretching exercises) | Group A (Decrease): | |||||||
Group A: 20 womensubjects who underwent relaxation training in the form of autogenic training (AT) Groups A + B: 3 treatments each week for 6 weeks + methyldopa. | Systolic: 13.75%, Diastolic: 12.88%, Proteinuria: 19.50% | |||||||
Group B (Decrease): | ||||||||
Systolic: 12.98%, Diastolic: 13.20%, Proteinuria: 17.17% | ||||||||
2 |
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2021 | China | Clinical Effects of Integrated Traditional Chinese and Western Medicine in Treating Severe Preeclampsia and Its Influence on Maternal and Infant Outcomes after Cesarean Section under Combined Lumbar and Epidural Anesthesia | 83 patients experimental group: self-made TCM decoction for oral administration (uncariae ramulus cum uncis (15 g), Salvia miltiorrhiza (15 g), Astragalus propinquus (15 g), puerariae lobamle radix (15 g), eucommiae cortex (12 g), leonuri herba (12 g), ginseng radix et aesare (10 g), paeoniae radix alba (10 g), poria (10 g), dioscoreae aesare (10 g), 5 g of angelicae sinensis radix, and 3 g of glycyrrhizae radix et aesare.) | 24 hours | 166 women with severe preeclampsia (SPE) | The combination of traditional Chinese and Western medicine can reduce the blood pressure of a patient with SPE. After the combined spinal-epidural anesthesia and caesarean section, it can significantly improve the maternal and infant outcomes and renal function, reduce inflammatory factors levels and body oxidative stress, and increase the activities of antioxidant enzymes. |
The total clinical effective rate of treatment in the experimental group was 90.36% and in the control group was 71.08% | ||||||||
83 patient control group: conventional treatments (magnesium sulfate injection) | ||||||||
3 |
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2013 | USA | Herb Use, Vitamin Use, and Diet in Low Income Postpartum Women | Women using herbs were significantly more likely to graduate high school (92% vs 78%, P=0.07) than non-herb users (65% vs 53%, P=0.03). Herb users were significantly more likely to report making any dietary change during their pregnancy than non-herb users (P=0.03), with 33% increasing their dairy intake and 51% eating more fruits. 58% reported making some other dietary changes, such as reducing salt intake (n=6), reducing caffeinated beverages and drinking more water (n=14), or eating less junk food (n=6). The most common herbal products women reported using during pregnancy were ginger (14%, n=22) and peppermint (14%, n=22). | 24 months | 160 prenatal women | Women with lower income are more likely to use herbal medicine for treatment. However, the use of herbs is rarely documented in inpatient medical records. From 160 participants, only 125 had documented use of prenatal vitamins and none had documented use of herbal medicine. |
4 |
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2016 | Iran | The Effect of Slow-Stroke Back Massage on the Anxiety Levels of Iranian Women on the First Postpartum Day | 100 participants which were primaporus women as signed to a massage therapy group (n = 50) or a control group (n = 50). | 4–18 hour | 100 primaporus woman | About 46% of the women had a secondary education, and 94% were homemakers. This represents a higher improvement of the anxiety in the intervention group than the control group after the intervention. A slow-stroke back massage in the first few days after delivery reduce maternal anxiety levels |
5 |
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2016 | Iran | Effect of lavender scent inhalation on prevention of stress, anxiety and depression in the postpartum period | The women divided into two groups. Group 1 (women with aromatherapy) Group 2 (non aromatherapy) The control group received routine care after discharge and was followed up by telephone only. | 8 hours | 140 women treated in the obstetrics and gynecology department | The study showed that using lavender and rose essential oils reduced anxiety and depression in students living in a hostel. Aromatherapy also led to a decrease in cortisol and an increase in serotonin levels, and improved the physical and psychological well-being of both women and infants after delivery, as well as promoting maternal-infant interaction. |
6 |
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2019 | Indonesia | The Effect of Warm Footbath with Salt of Edema Under Extremity in Postpartum Pre Eclamsia | Quasi-experimental pre-post test with control group design. | 15 minutes morning and evening for 3 days | The population was 9 respondents. | Soaking feet in warm salt water can reduce swelling in the legs, particularly in postpartum women with preeclampsia. This is because the warm salt water helps to dilate blood vessels and improve blood flow, reducing swelling. Midwives should encourage postpartum women experiencing leg swelling to try this method. |
The independent variable was soaking the foot using mixed salt warm water mixed. The dependent variable was extremity edema in the postpartum woman preeclampsia. The population was 9 respondents. Samples taken were 9 respondents | Samples taken were 9 respondents | |||||||
7 |
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2019 | Indonesia | MgSO4 And Slow Stroke Back Massage (SSBM) Therapy on Blood Pressure of Severe Preeclampsia Pregnant Women | Quasi-experimental design with the pre and post test perspective. | 32 respondents | The study found that combining MgSO4 therapy +SSBM significantly reduced blood pressure in severely preeclampsia pregnant women. The systolic blood pressure dropped from 168.63 to 151.94 with MgSO4 therapy and from 153.75 to 141.87 with the combination (MgSO4+SSBM). Similarly, diastolic blood pressure decreased from 104.44 to 94.81 with MgSO4 therapy and from 91.88 to 87.00 with combination (MgSO4+SSBM) therapy. | |
This research measured 32 the pregnant women with severe preeclampsia |
Fig.
Seven papers were located that addressed the use of nonconventional treatments for preeclampsia, some of which might be used in the postpartum period as well In light of Egypt (
Evidence suggests that a model for ensuring the continued use of newly acquired skills can be found in the results of a study conducted in Brazil by Lima et al. 2018, which examined the impact of an action-oriented educational intervention on the knowledge, attitudes, and practices (KAP) of community health workers (CHWs) in maternal and infant health(Lima et al. 2018). The intervention group participated in a 4-day interactive training course (
Traditional Chinese Medicine (TCM) is gaining popularity among pregnant women in Taiwan as a method of therapy for issues such as pregnancy-induced hypertension and morning sickness. TCM was developed in China. It is still not entirely understood whether or not preeclampsia may be effectively treated with traditional Chinese medicine (
The term “massage therapy” (often abbreviated as “MT”) refers to the systematic and intentional manipulation of soft tissue for therapeutic reasons (
Aromatherapy is one of the CAM (complementary and alternative medicine) subfields that is experiencing the most rapid expansion. “the therapeutic use of scents or at least of simple volatiles to treat or to ameliorate or to prevent sickness, infections, and indispositions exclusively by means of inhalation” is one definition of aromatherapy (
Soaking the feet (foot hydrotherapy) in warm salt water for 15 minutes twice a day for three days has been shown to reduce swelling in postpartum preeclampsia. As a form of detoxification, this treatment helps the body eliminate toxins by increasing blood flow and oxygen delivery to the swollen tissue through the dilation of blood vessels (
After birth, the mother’s body goes back to its pre-pregnancy state physiologically and anatomically. The postpartum period, sometimes called the puerperium, extends from the time of placental evacuation until the time when all of the newborn’s physiological systems have fully recovered (
Colostrum is an early form of breast milk that mothers produce in greater quantities in the postoperative period (
Women with preexisting hypertensive diseases are more likely to experience postpartum hypertension, however hypertension can also arise in this population (
The results depict that herbal ingredients are effective in treating preeclampsia after childbirth (
Reduce edema in the legs by soaking your feet in warm water with salt for 15 minutes each morning and night for three days. This is especially helpful for postpartum mothers who have developed preeclampsia. The average measurement of edema before and after the intervention was 16.33 and 12.27, respectively, demonstrating that this approach increases blood flow and lowers swelling (
Physical therapy, including stretching exercises, autogenic training, and slow-stroke back massage, has been shown to lower blood pressure in postpartum women in studies conducted by Awad in Egypt and Jahdi in Iran (
This study has several limitations that need to be considered. Firstly, there is a limited number of studies specifically focusing on CAM interventions for postpartum preeclampsia, necessitating the inclusion of studies on pre-eclampsia that may not directly apply to the postpartum period. Secondly, the variability in study designs, outcome measures, and participant characteristics adds complexity to drawing definitive conclusions. Additionally, the lack of standardized protocols and guidelines for CAM interventions in postpartum preeclampsia hampers consistent evaluation and comparison. Furthermore, the potential for publication bias and variations in the quality of included studies impact the overall strength of the evidence. Future research should address these limitations and prioritize targeted studies on CAM interventions specifically for postpartum preeclampsia to enhance the evidence base and inform clinical practice.
Our findings suggest midwives play a crucial role in providing comprehensive care for women during pregnancy, labor, and the postpartum period, including those with preeclampsia. They should possess the skills to promptly assess the situation and initiate appropriate therapies. Integrating complementary and alternative medicine approaches such as stretching exercises, autogenic training, herbal medication, lavender aromatherapy, slow-stroke back massage, dietary control, yoga, and warm foot therapy. Furthermore, herbal ingredients can promote blood circulation, improve the metabolic products in the blood of patients with hypertension and restore normal body function, nourish blood for regulating menstruation, regulate the metabolism of water and salt in the body, remove stasis, and calming. All of treatment can optimize the management of postpartum preeclampsia under the guidance of midwives. Collaboration with community health workers can enhance the provision of care. Clear guidelines and extensive training are essential for improving care for patients with preeclampsia. Future research should focus on implementing the knowledge gained thus far into targeted modules for the application of complementary and alternative medicine in postpartum preeclampsia therapy.
This study was supported by apt.Ikhwan Yuda Kusuma, S.Farm., M.Si., Beasiswa Pendidikan Indonesia (BPI) Kementrian Pendidikan dan Kebudayaan, Riset dan Teknologi and Universitas Harapan Bangsa, Purwokerto, Indonesia.