A, B. Effect of ibudilast and sulfasalazine on (A) disease activity index (DAI) and (B) macroscopic colonic scores (MAC). Data presented as mean ± SD for experimental groups. (***p < 0.001versus control group); and (###p < 0.001versus AA group). AA= acetic acid; C, D. Effect of ibudilast and sulfasalazine on (C) myeloperoxidase activity (MPO), and (D) histopathological changes score. Data presented as mean ± SD for experimental groups. (***p < 0.001versus control group); and (###p < 0.001versus AA group). AA= acetic acid.