Histopathological observation of the heart using H&E staining. a. negative control; b. positive control; c. MC Fruit ethanol extract 100 mg/kg b.w.; d. Spirulina platensis extract 100 mg/kg b.wt., and e. Combination of MC Fruit 50 mg/kg b.wt and Spirulina platensis 50 mg/kg b.wt. Leukocyte infiltration was observed in the myocardium cells of the positive control group, whereas the negative control group had adequate integrity (arrow).