Histopathological examination of heart tissue stained with H&E staining and 400× magnification. a Control group; b DM group; c DM+ISO group; d Liraglutide group; e Empagliflozin group, and f Combination group. The irregular arrangement of myocardial fibers and wide gap between cardiomyocytes (showed in black arrow) may indicate massive cardiomyocytes death. While massive infiltration of inflammatory cells with the absent of nuclei (showed in white arrow) may indicate coagulative necrosis.