Scheme-1, Reagents and conditions: (a) CH3COONa, reflux for 3hours (b) Na2CO3, H2O, reflux for 3-4 hours (c) - H2O.

 
 
  Part of: Kalli SB, Velmurugan V (2022) Design, synthesis and anti-diabetic activity of piperazine sulphonamide derivatives as dipeptidyl peptidase-4 inhibitors. Pharmacia 69(4): 987-993. https://doi.org/10.3897/pharmacia.69.e95096