Effects of Naloxone (Nal, 1 mg/kg, i.p) when co-administered with N/OFQ(1-13)NH2 and novel analogues [Orn9]N/OFQ(1-13)NH2, [Orn9,Orn13]N/OFQ(1-13)NH2 (all at a dose 10 µg/kg, i.p) on the pain threshold measured by PP test in male Wistar rats after 1hIS. Mean values ± S.E.M. are presented (*p < 0.05 vs. control; ++p < 0.01; +++p < 0.001 vs. 1hIS).

 
 
  Part of: Himcheva I, Stavreva GTz, Naydenova E, Bocheva A (2022) Involvement of the opioidergic and nociceptinergic systems in the analgesic effects of novel nociceptin analogues after acute and chronic immobilization stress. Pharmacia 69(4): 935-942. https://doi.org/10.3897/pharmacia.69.e89379