Effects of JTC-801 (0.5 mg/kg, i.p) co-administration with N/OFQ(1-13)NH2 and novel analogues [Orn9]N/OFQ(1-13)NH2, [Orn9,Orn13]N/OFQ(1-13)NH2 (all at a dose 10 µg/kg, i.p) on nociception measured by HP test in male Wistar rats after CIS. Mean values ± S.E.M. are presented (*p < 0.05; **p < 0.01 vs. control; +p < 0.05; ++p < 0.01 vs. CIS).

 
 
  Part of: Himcheva I, Stavreva GTz, Naydenova E, Bocheva A (2022) Involvement of the opioidergic and nociceptinergic systems in the analgesic effects of novel nociceptin analogues after acute and chronic immobilization stress. Pharmacia 69(4): 935-942. https://doi.org/10.3897/pharmacia.69.e89379