GSH/GPX4 axis (pathway). GPX4 converts GSH into oxidized glutathione (GSSG) and reduces the cytotoxic lipid peroxides (L-OOH) generated from membrane polyunsaturated fatty acids (PUFAs) to the corresponding alcohols (L-OH). The oxidized glutathione generated during the reduction of hydroperoxides by GPX4, is recycled by glutathione reductase (GR) and NADPH.

 
 
  Part of: Georgiev T, Hadzhibozheva P, Karamalakova Y, Georgieva E, Perinkadakatt F, Ilinov Z, Petkov K, Ananiev J (2022) Therapeutic approach of glutathione/glutathione peroxidase-4 axis modulation in the light of ferroptosis. Pharmacia 69(3): 839-846. https://doi.org/10.3897/pharmacia.69.e87716