Synthesis, docking study, and structure activity relationship of novel anti-tumor 1, 2, 4 triazole derivatives incorporating 2-(2, 3- dimethyl aminobenzoic acid) moiety

Hiba Alsaad; Ammar Kubba; Lubna H. Tahtamouni; Ali H. Hamzah

doi:10.3897/pharmacia.69.e83158

Omeed M. Hassan, Ammar A. Razzak Mahmood, Ali H. Hamzah, Lubna H. Tahtamouni (2022)
Design, Synthesis, and Molecular Docking Studies of 5‐Bromoindole‐2‐Carboxylic Acid Hydrazone Derivatives: In Vitro Anticancer and VEGFR‐2 Inhibitory Effects. ChemistrySelect 7: .

DOI: 10.1002/slct.202203726

Abbas A. Ridha Mehihi, Ammar A. Razzak Kubba, Wurood A. Shihab, Lubna H. Tahtamouni (2023)
New tolfenamic acid derivatives with hydrazine-1-carbothioamide and 1,3,4-oxadiazole moieties targeting VEGFR: synthesis, in silico studies, and in vitro anticancer assessment. Medicinal Chemistry Research 32: 2334.

DOI: 10.1007/s00044-023-03137-4

Yahya S. Yaseen, Ammar A.R. Mahmood, Ali H. Abbas, Wurood A. Shihab, Lubna H. Tahtamouni (2023)
New Niflumic Acid Derivatives as EGFR Inhibitors: Design, Synthesis, In silico Studies, and Anti-proliferative Assessment. Medicinal Chemistry 19: 445.

DOI: 10.2174/1573406419666221219144804

Abdullah Yahya Abdullah Alzahrani, Pratibha Gupta, Vijay Patil, Franz-Josef Meyer-Almes, D. V. Sokolova, V. S. Pokrovsky, C. S. Ramaa (2024)
Diaryl Pyrazoline, 1,3,4-Oxadizole, and 1,2,4-Triazole Pharmacophore Hybridization: Design, Synthesis, HDAC Inhibition, and Caspase 3/7 Activation Studies. Russian Journal of Bioorganic Chemistry 50: 375.

DOI: 10.1134/S1068162024020389

Mansour Nawasreh, Lubna Tahtamouni (2024)
Performance of Green Desymmetrization Methods toward Bioactive Cephalostatin Analogues. Current Medicinal Chemistry 31: 3327.

DOI: 10.2174/0929867330666230508145058

Rohit Pal, Ghanshyam Teli, Gurubasavaraja Swamy Purawarga Matada, Prasad Sanjay Dhiwar (2023)
Designing strategies, structural activity relationship and biological activity of recently developed nitrogen containing heterocyclic compounds as epidermal growth factor receptor tyrosinase inhibitors. Journal of Molecular Structure 1291: 136021.

DOI: 10.1016/j.molstruc.2023.136021

Mohammad Ajmal, Arun Kumar Mahato, Mausin Khan, Shivani Rawat, Asif Husain, Emad Bakheet Almalki, Mohammed Ahmed Alzahrani, Anzarul Haque, Mohammed Japer Mohammed Hakme, Ahmed Suleman Albalawi, Mohammad Rashid (2024)
Significance of Triazole in Medicinal Chemistry: Advancement in Drug Design, Reward and Biological Activity. Chemistry & Biodiversity 21: .

DOI: 10.1002/cbdv.202400637

Omeed M. Hassan, Ammar Kubba, Lubna H. Tahtamouni (2023)
Novel 5-bromoindole-2-carboxylic Acid Derivatives as EGFR Inhibitors: Synthesis, Docking Study, and Structure Activity Relationship. Anti-Cancer Agents in Medicinal Chemistry 23: 1336.

DOI: 10.2174/1871520623666230227153449

Abbas A. Mehihi, Ammar A. Kubba, Lubna H. Tahtamouni (2023)
Synthesis, Molecular Docking Studies, and In vitro Anticancer Evaluation of Novel Tolfenamic Acid Derivatives. Letters in Drug Design & Discovery 20: 1393.

DOI: 10.2174/1570180819666220831110423

Rohit Pal, Ghanshyam Teli, Gurubasavaraja Swamy Purawarga Matada, Prasad Sanjay Dhiwar (2023)
Nitrogen‐Containing Heterocyclic Scaffolds as EGFR Inhibitors: Design Approaches, Molecular Docking, and Structure‐Activity Relationships. ChemistrySelect 8: .

DOI: 10.1002/slct.202301200

Imad M. Al-Rubaye, Ammar A. Razzak Mahmood, Lubna H. Tahtamouni, Mai F. AlSakhen, Sana I. Kanaan, Khaled M. Saleh, Salem R. Yasin (2024)
In silico and in vitro evaluation of novel carbothioamide-based and heterocyclic derivatives of 4-(tert-butyl)-3-methoxybenzoic acid as EGFR tyrosine kinase allosteric site inhibitors. Results in Chemistry 7: 101329.

DOI: 10.1016/j.rechem.2024.101329

Mohammad H. Heriz, Ammar A. R. Mahmood, Salem R. Yasin, Khaled M. Saleh, Mai F. AlSakhen, Sana I. Kanaan, Nisreen Himsawi, Abdulrahman M. Saleh, Lubna H. Tahtamouni (2024)
Synthesis, docking study, and antitumor evaluation of benzamides and oxadiazole derivatives of 3‐phenoxybenzoic acid as VEGFR‐2 inhibitors. Drug Development Research 85: .

DOI: 10.1002/ddr.22186

Hiba N. Alsaad, Baan M. AL‐Jasani, Ammar A. Razzak Mahmood, Lubna H. Tahtamouni, Khaled M. Saleh, Mai F. AlSakhen, Sana I. Kanaan, Salem R. Yasin (2024)
Novel 1,3,4‐oxadiazole derivatives of naproxen targeting EGFR: Synthesis, molecular docking studies, and cytotoxic evaluation. Drug Development Research 85: .

DOI: 10.1002/ddr.22231

Zuhal KARAGÖZ, Umut İbrahim OGUZ, Murat GENÇ (2023)
Synthesis, Solvatochromic Analysis and Theoretical Studies of 3-((1H-benzo[d][1,2,3]triazole-1-yl)methyl)-4- phenylethyl -1H-1,2,4-triazole-5(4H)-thione. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi 12: 568.

DOI: 10.17798/bitlisfen.1279575

Agnieszka Czylkowska, Suneel Lanka, Małgorzata Szczesio, Kamila Czarnecka, Paweł Szymański, Monika Pitucha, Aneta Drabińska, Bruno Cury Camargo, Jacek Szczytko (2022)
New Derivatives of 5-((1-Methyl-Pyrrol-2-yl) Methyl)-4-(Naphthalen-1-yl)-1,2,4-Triazoline-3-Thione and Its Coordination Compounds with Anticancer Activity. International Journal of Molecular Sciences 23: 9162.

DOI: 10.3390/ijms23169162