Research Article
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Article title
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Abstract
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Keywords
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Introduction
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Experimental part
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Material and methods
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Chemical synthesis
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Synthesis of methyl ester derivatives: compounds (3 and 4)
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Synthesis of aryl hydrazide derivatives: compounds (5 and 6)
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Synthesis of carbothioamide derivatives compounds (H 1-6)
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Synthesis of 1,2,4 triazole derivatives, compounds (H 7-12)
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Synthesis of amide derivatives (compounds HB 1-6)
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Docking study
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Method of the docking study
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In silico ADMET and drug-likeness prediction
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Biological study
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Cell culture
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In vitro MTT cell proliferation assay
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Cell cycle analysis
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Detection of apoptosis/necrosis
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Quantitative reverse transcription-polymerase chain reaction (qRT-PCR)
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Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitory assay
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Statistical analysis
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Results and discussion
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Docking study
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In silico ADMET and Drug likeness prediction
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Biological study
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The newly synthesized 1,2,4 triazole derivatives (HB1-6) are cytotoxic to cancer cells
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Compound HB5-treated Hep G2 hepatocyte carcinoma cells are arrested at S and G2/M cell cycle phases
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Cytotoxicity of compound HB5 is attributed to apoptosis not necrosis
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Compound HB5 inhibited Hep G2 cell proliferation and induced apoptosis by inhibiting EGFR tyrosine kinase
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Structure-Activity Relationship (SAR) of compounds HB1-HB6
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Conclusion
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Conflict of Interest
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Acknowledgements
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References
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Supplementary materials
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