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  • Article title
  • Abstract
  • Keywords
  • Introduction
  • Materials and methods
    • Chemicals and reagents
    • Chromatographic system and conditions
    • Preparation of the stock solution
    • Samples preparation
    • Preparation of buffer solutions
  • Results and discussion
    • Synthesis of 2-(5-(4-chlorophenyl)-3-(ethoxycarbonyl)-2-methyl-1H-pyrrol-1-yl) propanoic acid
    • Development of the used RP-HPLC method
    • Validation of a HPLC analytical procedure
    • System suitability test (SST)
    • Selectivity
    • Linearity
    • Precision
    • Accuracy
    • Identification of process related impurities
    • Determination of degradation at different pH
    • Stability determination of 2-(5-(4-chlorophenyl)-3-(ethoxycarbonyl)-2-methyl-1H-pyrrol-1-yl)propanoic acid at pH 7.4 (blood plasma) and temperature of 37 °C
    • Stability determination of compound 2-(5-(4-chlorophenyl)-3-(ethoxycarbonyl)-2-methyl-1H-pyrrol-1-yl)propanoic acid at pH 9.0 (intestine) and temperature of 37 °C
  • Conclusion
  • Conflict of interest
  • Acknowledgements
  • References
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