Design of the theranostic nanomachine for targeting and cleavage of RNA. Reaction 1: the nanomachine strand with Dz1 catalytic core (deoxyribozyme) bind to a specific site of the target RNA by Watson-Crick base pairing and cleave the chain. Reaction 2: a binary sensor hybridizes in complementary approach to form Dz2 core, which is able to react with a fluorescent reporter. Reaction 3: Dz2 core cleaves the fluorescent reporter and induces a fluorescent signal with increased intensity.