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  • Article title
  • Abstract
  • Keywords
  • Introduction
  • Materials and methods
    • Chemicals and materials
    • Preparation of super saturable quercetin - self-nano emulsifying (SSQ-SNE)
    • Design of experiment for screening component SSQ-SNE
    • Chemometrics analysis for study at run formula
    • Droplet size, polydispersity index, zeta potential, and mobility
    • Measurement of emulsification time, viscosity, and drug load
    • Percentage of clarity studies
    • Thermodynamic stability studies
    • Morphology characterization and interaction studies
  • Result and discussion
    • Fractional factorial design for screening component SSQ-SNE
    • Principal component analysis and cluster analysis on the FrFD
    • Selected formulas and verification of results
    • Characterization and evaluation of selected SSQ-SNE
      • Appearance, drug load, and viscosity
      • Emulsification time
      • Morphology, droplet size, and polydispersity index
      • Zeta potential and electrophoretic mobility
    • Analysis of SSQ-SNE components using FTIR-ATR
    • Thermodynamic stability of SSQ-SNE and nanoemulsions
  • Conclusion
  • Funding
  • Acknowledgment
  • References
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