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  • Article title
  • Abstract
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  • Introduction
  • Materials and methods
    • Materials
    • Atorvastatin ascorbic acid cocrystals preparation
    • Drug content determination
    • Fourier transformation infrared (FT-IR) spectroscopy
    • Differential scanning calorimetry (DSC)
    • Scanning electron microscopy (SEM)
    • X-Ray powder diffraction (XRD)
    • In vitro dissolution studies
  • Evaluation of safety and efficacy of atorvastatin ascorbic acid cocrystal formulation
    • Animals
    • Preparation of hyperlipidemic rats (Sampathkumar et al. 2011)
    • Statistical analysis
  • Results and discussion
    • Percentage of yield
    • FT-IR spectroscopy
    • Differential scanning calorimetry
    • Scanning electron micrograph
    • Powder X-ray diffraction
    • Dissolution studies
    • Effect of unprocessed ATV and AAC on liver SGPT, SGOT in hyperlipidemic rats
    • Effect of unprocessed ATV and AAC on total cholesterol and triglycerides in hyperlipidemic rats
    • Effect of unprocessed ATV and AAC on liver reduced glutathione (GSH) level in hyperlipidemic rats
  • Conclusion
  • Conflict of interest
  • Acknowledgements
  • References
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