A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity

Ali H. Abbas; Ammar A. Razzak Mahmood; Lubna H. Tahtamouni; Zainab A. Al-Mazaydeh; Majdoleen S. Rammaha; Fatima Alsoubani; Rheda I. Al-bayati

doi:10.3897/pharmacia.68.e70654

Abbas A. Mehihi, Ammar A. Kubba, Lubna H. Tahtamouni (2023)
Synthesis, Molecular Docking Studies, and In vitro Anticancer Evaluation of Novel Tolfenamic Acid Derivatives. Letters in Drug Design & Discovery 20: 1393.

DOI: 10.2174/1570180819666220831110423

Shaker A. Abdul Hussein, Ammar Kubba, Asim A. Balakit, Lubna H. Tahtamouni, Ali H. Abbas (2023)
Design, Synthesis, in silico and in vitro Evaluation of New Combretastatin A-4 Analogs as Antimitotic Antitumor Agents. Medicinal Chemistry 19: 1018.

DOI: 10.2174/1573406419666230530155741

Omeed M. Hassan, Ammar Kubba, Lubna H. Tahtamouni (2023)
Novel 5-bromoindole-2-carboxylic Acid Derivatives as EGFR Inhibitors: Synthesis, Docking Study, and Structure Activity Relationship. Anti-Cancer Agents in Medicinal Chemistry 23: 1336.

DOI: 10.2174/1871520623666230227153449

Wurood A. Shihab, Ammar A. Razzak Mahmood, Lubna H. Tahtamouni, Mai F. AlSakhen, Sana I. Kanaan, Khaled M. Saleh, Salem R. Yasin (2024)
In vitro and in silico evaluation of 4'-hydroxy-[1,1'-biphenyl]-4-carbohydrazide Schiff base and oxadiazole derivatives targeting EGFR allosteric site. Chemical Papers 78: 7951.

DOI: 10.1007/s11696-024-03648-3

Yaseen S. Hamdoon, Mohammed K. Hadi (2024)
Molecular docking, ADMET, synthesis and evaluation of new indomethacin hydrazide derivatives as antibacterial agents. Pharmacia 71: 1.

DOI: 10.3897/pharmacia.71.e127784

Omeed M. Hassan, Ammar A. Razzak Mahmood, Ali H. Hamzah, Lubna H. Tahtamouni (2022)
Design, Synthesis, and Molecular Docking Studies of 5‐Bromoindole‐2‐Carboxylic Acid Hydrazone Derivatives: In Vitro Anticancer and VEGFR‐2 Inhibitory Effects. ChemistrySelect 7: .

DOI: 10.1002/slct.202203726

Yahya S. Yaseen, Ammar A.R. Mahmood, Ali H. Abbas, Wurood A. Shihab, Lubna H. Tahtamouni (2023)
New Niflumic Acid Derivatives as EGFR Inhibitors: Design, Synthesis, In silico Studies, and Anti-proliferative Assessment. Medicinal Chemistry 19: 445.

DOI: 10.2174/1573406419666221219144804

Mustafa M. Allawi, Ammar A. Razzak Mahmood, Lubna H. Tahtamouni, Mai F. AlSakhen, Sana I. Kanaan, Khaled M. Saleh, Salem R. Yasin (2024)
New Indole‐6‐Carboxylic Acid Derivatives as Multi‐Target Antiproliferative Agents: Synthesis, in Silico Studies, and Cytotoxicity Evaluation. Chemistry & Biodiversity : .

DOI: 10.1002/cbdv.202301892

Mohammad H. Heriz, Ammar A. R. Mahmood, Salem R. Yasin, Khaled M. Saleh, Mai F. AlSakhen, Sana I. Kanaan, Nisreen Himsawi, Abdulrahman M. Saleh, Lubna H. Tahtamouni (2024)
Synthesis, docking study, and antitumor evaluation of benzamides and oxadiazole derivatives of 3‐phenoxybenzoic acid as VEGFR‐2 inhibitors. Drug Development Research 85: .

DOI: 10.1002/ddr.22186

Mustafa M Allawi, Ammar A Razzak Mahmood, Lubna H Tahtamouni, Abdulrahman M Saleh, Sana I Kanaan, Khaled M Saleh, Mai F AlSakhen, Nisreen Himsawi, Salem R Yasin (2024)
Anti-proliferation evaluation of new derivatives of indole-6-carboxylate ester as receptor tyrosine kinase inhibitors. Future Medicinal Chemistry 16: 1313.

DOI: 10.1080/17568919.2024.2347084

Ruta D. Khonde, Mayuresh V. Shivramwar (2024)
Equilibrium and kinetic investigation of reactive extraction of pyridine-2-carboxylic acid using corn oil as diluent. Brazilian Journal of Chemical Engineering : .

DOI: 10.1007/s43153-024-00441-3

Yahya Yaseen, Ammar Kubba, Wurood Shihab, Lubna Tahtamouni (2022)
Synthesis, docking study, and structure-activity relationship of novel niflumic acid derivatives acting as anticancer agents by inhibiting VEGFR or EGFR tyrosine kinase activities. Pharmacia 69: 595.

DOI: 10.3897/pharmacia.69.e86504

Shaker A. Abdul Hussein, Ammar A. Razzak Mahmood, Lubna H. Tahtamouni, Asim A. Balakit, Yahya S. Yaseen, Rehab A. Al‐Hasani (2023)
New Combretastatin Analogs as Anticancer Agents: Design, Synthesis, Microtubules Polymerization Inhibition, and Molecular Docking Studies. Chemistry & Biodiversity 20: .

DOI: 10.1002/cbdv.202201206

Abbas A. Ridha Mehihi, Ammar A. Razzak Kubba, Wurood A. Shihab, Lubna H. Tahtamouni (2023)
New tolfenamic acid derivatives with hydrazine-1-carbothioamide and 1,3,4-oxadiazole moieties targeting VEGFR: synthesis, in silico studies, and in vitro anticancer assessment. Medicinal Chemistry Research 32: 2334.

DOI: 10.1007/s00044-023-03137-4

Sana Razhan M. Alsubaiei, Hanan A. Alfawaz, Musarat Amina, Nawal M. Al Musayeib, Afaf El-Ansary, Syed Rizwan Ahamad, Omar M. Noman, Jaber A. Maini, Dario Pasini (2022)
Comparative Chemical Profiling and Biological Potential of Essential Oils of Petal, Choke, and Heart Parts of Cynara scolymus L. Head. Journal of Chemistry 2022: 1.

DOI: 10.1155/2022/2355004

Imad M. Al-Rubaye, Ammar A. Razzak Mahmood, Lubna H. Tahtamouni, Mai F. AlSakhen, Sana I. Kanaan, Khaled M. Saleh, Salem R. Yasin (2024)
In silico and in vitro evaluation of novel carbothioamide-based and heterocyclic derivatives of 4-(tert-butyl)-3-methoxybenzoic acid as EGFR tyrosine kinase allosteric site inhibitors. Results in Chemistry 7: 101329.

DOI: 10.1016/j.rechem.2024.101329

Yasemin Ünver, Fatih Çelik, Ali Aydın, Nevin Süleymanoğlu, Reşat Ustabaş, Halil İbrahim Güler, Kadriye İnan Bektaş (2024)
New 1,2,4-triazol-3-one derivatives with 4-fluorobenzene: Synthesis, characterization, DFT, antimicrobial-antiproliferative activities and molecular docking study. Journal of Molecular Structure 1305: 137806.

DOI: 10.1016/j.molstruc.2024.137806