The effect of the 24 h treatment with (TOPO (2 or 5 µM) + carvacrol (166 µM)) combination on TOPO cellular uptake in (A) HeLa, (B) HCT116, (C) MCF-7, (D) HepG2, (E) SKOV3 and (F) A549 cell lines. Data were expressed as mean ± SD (error bars), n = 3. The significant differences between the different (TOPO + carvacrol (166 µM)) combinations at each time assessed by mesuring the P-values using the independent t-test, were classified to * P < 0.05.