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  • Article title
  • Abstract
  • Keywords
  • Introduction
  • Materials and methods
    • Materials and Instrumentation
    • Validation method
      • System suitability test (SST)
      • Linearity, the limit of detection (LoD), and limit of quantitation (LoQ)
    • Accuracy and precision
    • Formula optimization
    • Chemometrics
    • Release kinetic study
  • Results and discussion
    • Method validation
    • Accuracy and precision
    • Formula optimization
    • Chemometrics responses analysis
    • Optimum formula verification
    • Release kinetics determination
  • Conclusions
  • Acknowledgment
  • References
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