Fluorescence images (x400) of DAPI-stained HeLa cells treated with different formulations for 24 h. The treated cancer cells showed nuclear abnormalities. ($,*P <0.05, **,$$p < 0.01, ***,$$$p <0.001, NS = not significant). The symbol * indicates differences between MC and REO/NE; $ indicates differences between REO/NE + MC and each of the individual treatments. Data shown are results of a minimum of three independent experiments.