Alpha-amylase enzyme inhibting activity (IC50(µM) of palmatine, glimepiride, metformin and standard drug(acarbose). The result are shown as Mean ± standard deviation in triplicates (n = 3). The data were statistically analyzed by One-way ANOVA followed by Dunnet’s post hoc test. Graph showed that acarbose(a) vs. glimepiride = p < 0.001 = c; acarbose vs. metformin = p < 0.01 = b; acarbose vs. palmatine = p < 0.0001 = d. Glimepiride vs. Metformin = p < 0.001 = c, glimepiride vs. palmatine = p < 0.0001 = d, metformin vs. palmatine = p < 0.0001 = d.