Some of the potential biological targets of Cannabidiol (CBD): cannabinoid receptors CB1, and CB2; ion channel receptors, incl. transient receptor potential vanilloid (TRPV) type 1 and 2; EGF-R, epidermal-growth factor receptor; ‘orphan’ G protein-coupled receptors, GPR55 and GPR3, GPR6; peroxisome proliferator-activated receptor, PPAR; vascular endothelial growth factor, VEGF-R; allosteric modulation and enhanced activity at αIγ glycine receptor; enhanced activity at the 5-HT1a, adenosine and N-acetylcholine receptors; inhibiting activity on mu and delta opioid receptors. Note: (+) stimulation; (-) inhibition.