Formation of a 6-membered ring in 6d due to an intramolecular hydrogen bond.

 
 
  Part of: Mitkov J, Kondeva-Burdina M, Zlatkov A (2019) Synthesis and preliminary hepatotoxicity evaluation of new caffeine-8-(2-thio)-propanoic hydrazid-hydrazone derivatives. Pharmacia 66(3): 99-106. https://doi.org/10.3897/pharmacia.66.e37263