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  • ContentsContents
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  • Article title
  • Abstract
  • Keywords
  • Introduction
  • Materials and methods
    • P. macrocarpa leaves extraction
    • RAW 264.7 cell culture
    • Preparation of the extract treatment
    • Nitric oxide (NO) assay
    • Cell viability assay
    • Flow cytometry analysis
    • Identification of bioactive compounds using LC-HRMS
    • In silico study
      • Compound bioactivity screening
      • Target protein prediction
      • Molecular docking
      • Molecular dynamics simulation
    • Statistical analysis
  • Results
    • Effects of P. macrocarpa leaf extract on NO production and cell viability
    • Effect of P. macrocarpa leaf extract on iNOS expression and IL-1β levels
    • Identification of bioactive compound in P. macrocarpa leaf extract
    • Anti-inflammatory properties screening
    • Target protein prediction
    • Molecular docking analysis
    • Molecular dynamics simulation
  • Discussion
  • Conclusion
  • Additional information
  • References
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