Novel spirooxindole compounds as anticancer agents: targeting Plk4 kinase through design, synthesis, and molecular docking


	Two-dimensional analysis of spirooxindole derivatives 4b (R = methyl) and 4i (R = p-hydroxybenzyl) within the ATP binding pocket of Plk4 (PDB ID: 4JXF, resolution 2.40 Å).

Part of: Sammor MS, Habashneh AY, Al-Sha'er MA, Bardaweel SK, El‐Abadelah MM (2025) Novel spirooxindole compounds as anticancer agents: targeting Plk4 kinase through design, synthesis, and molecular docking. Pharmacia 72: 1-13. https://doi.org/10.3897/pharmacia.72.e149240