A. The co-crystallized spiro ligand (631301); B. The co-crystallized pose and the docked pose of the co-crystallized ligand (631301) with RMSD < 2.00 Å; C. The binding site of the Plk4 kinase protein (PDB code: 4JXF, resolution: 2.40 Å). Red represents the co-crystal compounds, and green represents the highest LibDock score compound (LibDock score = 178.9); D. Two-dimensional analysis of the co-crystallized ligand (631301) in the ATP binding pocket of Plk4.

 
 
  Part of: Sammor MS, Habashneh AY, Al-Sha'er MA, Bardaweel SK, El‐Abadelah MM (2025) Novel spirooxindole compounds as anticancer agents: targeting Plk4 kinase through design, synthesis, and molecular docking. Pharmacia 72: 1-13. https://doi.org/10.3897/pharmacia.72.e149240