Chemical structures of sunitinib, olaparib, mitoxantrone, and bicalutamide (a). MERS protease inhibition by sunitinib, olaparib, mitoxantrone, and bicalutamide (b). Dose response curve B. Percent inhibition, dose response curve of MERS-CoV Plpro inhibition identified from the IC50 protease inhibition assay with dissociation of RLRGG-AMC substrate. Values represent the average ±standard deviation of three replicates.

 
 
  Part of: Alaofi AL, Shahid M, Kalam MA (2025) Inhibition of MERS-CoV papain-like protease by sunitinib: In vitro and in silico investigations. Pharmacia 72: 1-12. https://doi.org/10.3897/pharmacia.72.e141634