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  • Article title
  • Abstract
  • Keywords
  • Introduction
  • Methods
    • Ethical approval
    • Study design and settings
    • Special considerations to minimize the suffering and distress of animals
    • Sample collection
    • Assessment of biochemical analysis
    • Determination of mRNA expression of CYP3A4 and NF-KB in liver tissue
    • Histopathological examination
    • Sample size calculation and animal randomization
    • Statistical analysis
  • Results
    • Effect of PTX on serum AST and ALT activity
    • Effect of PTX on Serum MDA and GSH
    • Effect of PTX on CYP3A4 and NF-KB gene expression in liver toxicity
    • Histological changes
    • Comparison of histological scores among study groups
  • Discussion
  • Study limitations
  • Conclusions
  • Additional information
  • References
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