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  • Article title
  • Abstract
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  • Introduction
  • Materials and methods
    • Chemicals and materials
    • Characterization methods
    • Molecular structure synthesis
      • Synthesis of chalcone derivatives (1–5)
      • The following is a general method for synthesizing pyrazoline derivatives (6–10)
      • The compound (1) is (E)-3-(4-methoxyphenyl)-1-(pyridine-2-yl) prop-2-en-1-one
      • The compound (2) is (E)-3-(4-nitrophenyl)-1-(pyridin-2-yl) prop-2-en-1-one
      • The compound (3) is (E)-3-(4-(dimethylamino) phenyl)-1-(pyridin-2-yl) prop-2-en-1-one
      • The compound (4) is (E)-3-(4-chlorophenyl)-1-(pyridin-2-yl) prop-2-en-1-one
      • The compound (5) is (E)-3-phenyl-1-(pyridine-2-yl) prop-2-en-1-one
      • The compound (6) is 4-(5-(4-methoxyphenyl)-3-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamide
      • The compound (7) is 4-(5-(4-nitrophenyl)-3-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamide
      • 4-(5-(4-(dimethylamino) phenyl)-3-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamide (8)
      • The compound (9) is 4-(5-(4-chlorophenyl)-3-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamide
      • The compound (10) is 4-(5-phenyl-3-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamide
    • Methods of computation
    • ADME procedures
    • Ligands and receptor preparation
    • Molecular docking protocol
    • Antiproliferative ASSAY
    • Determining the value of the half-maximum inhibitory concentration (IC50)
    • Quantitative analysis of data using statistical methods
  • Results and discussion
    • Analysis of the ADME findings
    • Analysis of docking final results
    • Analyzing results from anti-breast cancer tests
  • Conclusion
  • Author contributions
  • Acknowledgments
  • References
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