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Top four siRNA candidates bound to Ago2 with their respective docking scores. All siRNA candidates had highly negative docking scores and interacted with residues in both the PAZ and MID domains. A. s3; B. s19; C. s22; D. s28; E. s0. |
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| Part of: Fajardo LE, Macalalad MA, Odchimar NM, de Guzman JC, Orosco F (2024) Computational design and validation of siRNA molecules to silence oncogenic CTNNB1 mRNA as a potential therapeutic strategy against hepatitis B/C virus-associated hepatocellular carcinoma. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e127981 |