Secondary structures of the siRNA guide strands and their free energies of folding. A positive free energy of folding indicates a higher binding efficiency, as the molecule is less prone to secondary structure formation. A. s3; B. s19; C. s22; D. s28.

 
 
  Part of: Fajardo LE, Macalalad MA, Odchimar NM, de Guzman JC, Orosco F (2024) Computational design and validation of siRNA molecules to silence oncogenic CTNNB1 mRNA as a potential therapeutic strategy against hepatitis B/C virus-associated hepatocellular carcinoma. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e127981