Graphical representation of the RNAi pathway for siRNAs. The siRNA guide strand is loaded onto Ago2, while the passenger strand is discarded. Ago2 associates with other proteins to form RISC and facilitates binding of the guide strand to a complementary mRNA sequence. The endonuclease activity of Ago2 cleaves the mRNA, thereby silencing its expression. Ago2, Argonaute 2.

 
 
  Part of: Fajardo LE, Macalalad MA, Odchimar NM, de Guzman JC, Orosco F (2024) Computational design and validation of siRNA molecules to silence oncogenic CTNNB1 mRNA as a potential therapeutic strategy against hepatitis B/C virus-associated hepatocellular carcinoma. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e127981