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  • ContentsContents
  • Article InfoArticle Info
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  • Article title
  • Abstract
  • Keywords
  • Introduction
  • Methodology
    • General
    • Chemical synthesis
      • Synthesis of 3,4,5-trihydroxybenzohydrazide (compound 1)
      • General procedure for preparation of the target hybrids (3a–d)
      • 3,4,5-Trihydroxy-N’-(2-oxoindolin-3-ylidene)benzohydrazide (3a)
      • 3,4,5-trihydroxy-N’-(5-methoxy-2-oxoindolin-3-ylidene) benzohydrazide(3b)
      • N’-(5-Bromo-2-oxoindolin-3-ylidene)-3,4,5-trihydroxybenzohydrazide(3c)
      • N’-(5-fluoro-2-oxoindolin-3-ylidene)-3,4,5-trihydroxybenzohydrazide(3d)
    • Assay of biological activity
      • Antioxidant activity assay (in vitro)
      • Cytotoxicity assay (in vitro)
    • In silico study
  • Results
    • Chemistry
    • In vitro study
      • Antioxidant activity
      • Cytotoxic activity (MTT assay method)
    • Molecular docking study
    • Regarding EGFR
    • RNA polymerase
  • Discussion
    • Antioxidant effect
    • Cytotoxic effect
    • Discussion regarding EGFR
    • Discussion regarding RNA polymerase
  • Conclusion
  • Ethics Statements
  • Author Contribution
  • Data availability
  • Acknowledgments
  • References
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