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  • ContentsContents
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  • Article title
  • Abstract
  • Keywords
  • Introduction
  • Materials and methods
    • Abbreviations
    • Materials
    • Preparation of TDA nanocrystals
    • Characterization of TDA nanocrystals
    • Particle size, polydispersity indices, and zeta potential determination
    • Saturation solubility determination
    • Encapsulation efficiency determination
    • In vitro dissolution study
    • Fourier transform infrared (FTIR)
    • X-ray powder diffraction (XRPD)
    • Differential scanning calorimetric (DSC)
    • Morphological characterization
    • Effects of aging
    • Animals
    • Pharmacokinetic study
      • Pharmacokinetic analysis
    • Statistical analysis
  • Results and discussion
    • Particle size, polydispersity index, and zeta potential
    • Saturation solubility
    • Encapsulation efficiency
    • In vitro dissolution study
    • FTIR
    • DSC
    • XRPD
    • SEM
    • Effects of aging
    • Pharmacokinetics of pure TDA and TDA NCs
  • Conclusions
  • Authors’ contributions
  • Compliance with ethical standards
  • Acknowledgments
  • References
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