Hormonal and metabolic serum levels. Changes in serum levels of testosterone, estradiol, progesterone, and glucose before and after treatment with metformin, curcumin, metformin + curcumin, and olive oil compared to control rats. Data expressed as mean ± SEM (n = 16–17). *Significantly different form control. A. Testosterone levels in ng/ml following letrozole injections and before treatment at age 9 weeks; B. Estradiol levels in pg/ml following letrozole injections and before treatment at age 9 weeks; C. Progesterone levels in ng/ml following letrozole injections and before treatment at age 9 weeks; D. Glucose serum levels mg/dl following letrozole injections and before treatment at age 9 weeks; E. Testosterone levels in ng/ml following treatment at age 12 weeks; F. Estradiol levels in pg/ml following treatment at age 12 weeks; G. Progesterone levels in ng/ml following treatment at age 12 weeks; H. Glucose serum levels mg/dl following treatment at age 12 weeks.