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  • Article title
  • Abstract
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  • Introduction
  • Materials and methods
    • Materials
    • Optimization of formulation variables
    • Preparation of PZS-HGMG
    • Characteristics of the PZS-HGMG
      • Microcapsule diameter analysis
      • Swelling experiments (SW%)
      • Encapsulation efficiency (EE%)
      • SEM analysis
      • FTIR analysis for an optimized formula
      • DSC studies for an optimized formula
    • In vitro drug release
    • In vivo anti-ulcerogenic study
    • Histological assessment of rats’ gastric tissues
    • Ethical approval
    • Statistical analysis
  • Results and discussion
    • Formulation and optimization using a Box-Behnken design
      • Diameter
      • Swelling (%)
      • Drug encapsulation efficiency (EE%)
    • Development of the optimized model
      • Particle size (PS)
      • Swelling (%)
      • Encapsulation efficacy (%) (EE%)
      • Effect of SAT
      • Effect of CaCl 2
      • Effect of CTN
    • Selection of the optimized formula
    • Morphology of an optimized formula
    • 3.5 FTIR analysis
    • DSC for optimized formula
    • In vitro release and kinetic analysis
    • In vivo treatment efficacy
      • Evaluation of gastric tissue macroscopic injuries
      • Histopathological analysis
  • Conclusion
  • Funding
  • Competing interests
  • Consent to participate
  • References
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