A. The co-crystallized pyrimidine ligand (1IEP); B. The co-crystallized pose and the docked pose of the co-crystallized ligand with RMSD = 2.10 Å; C. The binding site of the c-Abl-kinase protein (PDB code: 1IEP, resolution: 2.10 Å). Blue is for the co-crystal compounds, and red is for the highest Libdock score compound (Libdock score = 169.76).