Histology of cardiac tissue stained with HE which assess the necrosis, congestion, and oedema (N: normal rats, ISO: ISO 85 mg/kgbw ,ISO+QR: ISO 85 mg/kgbw + 100 mg/kgbw quercetin. ISO+VA100: ISO 85 mg/kgbw + 100 mg/kgbw VAEE, ISO+VA300: ISO 85 mg/kgbw + 300 mg/kgbw VAEE, ISO+VA500: ISO 85 mg/kgbw + 500 mg/kgbw VAEE, black arrow show aggregation while red arrow show necrotic, 400× magnification, , the data were presented in mean ± standard error of the mean (SEM). (*: p<0,05, **: p<0,01, ***: p<0.001, P>0.05 ns/not significance).