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  • Article title
  • Abstract
  • Keywords
  • Introduction
  • Materials and methods
    • Materials
    • Construction of pseudoternary phase diagram
    • Preparation of microemulsion
    • Measurement of particle size, PDI and zeta potential
    • Visual inspection and centrifugation test
    • Dilution test
    • EC test
    • Physical stability tests
    • pH measurement
    • Content uniformity test
    • In vitro drug release
    • Preparation of ME-based hydrogel
    • Visual appearance
    • pH measurement
    • Spreadability test
    • Viscosity and rheology studies
    • Ex vivo permeability study
    • Ex vivo skin deposition study
    • Statistical analysis
  • Results and discussion
    • Pseudoternary phase diagram
    • Particle size and PDI of vemurafenib ME
    • Visual inspection and centrifugation results of vemurafenib MEs
    • Dilution test results
    • EC of vemurafenib ME
    • pH measurement of vemurafenib ME
    • Content uniformity of vemurafenib ME
    • In vitro drug release of vemurafenib ME
    • Selection of best vemurafenib me
    • Visual appearance, pH and spreadability of ME-based hydrogels
    • Viscosity and rheology study
    • Ex vivo permeability
  • Conclusion
  • Acknowledgments
  • References
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