Effect of TMNB on glutamate-induced paw licking in mice. The animals were divided into five groups, and each group contained six male mice. The mice were injected intraperitoneally with either 5% DMSO (vehicle) or TMNB at doses of 50, 100, 150, and 200 µg/kg. After 60 minutes, 20 µL of glutamate was intraplantarly administered into the right hind paw, and the licking time was recorded. *P<0.001 indicating a significant reduction of the percent of inhibition compared to the control group. #P<0.001 indicating a significant reduction in licking time compared to the control group.