Effect of TMNB on capsaicin-induced paw licking in mice. The animals were divided into five groups, and each group contained six male mice. The mice were injected with either 5% DMSO (vehicle), TMNB at doses of 50, 100, 150, and 200 µg/kg (i.p.), or the capsaicin antagonist, capsazepine (Capsz, 0.17 mmol/kg, i.p.). After 60 minutes, the mice were challenged with capsaicin, and the licking time was recorded. **P<0.01 indicating a significant reduction of the percent of inhibition compared to the control group. ##P<0.01 indicating a significant reduction in licking time compared to the control group.