Effect of TMNB on mice (n=6) in the hot plate test. The statistical analysis showed that TMNB caused a significant difference compared to the vehicle (5% DMSO) with ***P<0.001. Additionally, Nal blocked the effect of 200 μg/kg TMNB and 5 mg/kg morphine with ###P<0.001. (NAL: naloxone, Mor: morphine). $ denotes the difference between Nal + Mor compared to Mor alone.

 
 
  Part of: Bseiso Y, Alqudah A, Qnais E, Wedyan M, Abu-Safieh K, Gammoh O (2023) 2ʹ,3,3,5ʹ-Tetramethyl-4ʹ-nitro-2ʹH-1,3ʹ-bipyrazole exerts antinociceptive effect using various nociception models. Pharmacia 70(3): 509-517. https://doi.org/10.3897/pharmacia.70.e104828